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Showing posts with label science. Show all posts
Showing posts with label science. Show all posts

Friday, November 22, 2019

Medial Compartment of the Thigh Anatomy

Medial Compartment of the Thigh Anatomy


Medial Compartment of the Thigh Anatomy
The medial compartment of the thigh is wedge­shaped and lies between the anterior and posterior compartments. It contains pectineus, adductors longus, brevis and magnus, gracilis and obturator externus. The obturator nerve and vessels and the profunda femoris vessels, together with their perforating branches, supply the compartment.
Anterior Compartment of the Thigh Anatomy

Anterior Compartment of the Thigh Anatomy


Anterior Compartment of the Thigh Anatomy
The anterior compartment is the largest in the thigh, occupying the region between the inguinal ligament and the knee. Lateral and anteromedial intermuscular septa separate the contents from the posterior (hamstring) and medial (adductor) compartments, respectively (Fig. 6.2). The anterior compartment (Fig. 6.12) contains quadriceps femoris, sartorius and the tendon of iliopsoas, and is innervated by the femoral nerve. The femoral artery and vein, the principal vessels of the lower limb, traverse the compartment and leave via the opening in adductor magnus to gain the popliteal fossa.

Thursday, November 21, 2019

Pelvic Cavity Anatomy

Pelvic Cavity Anatomy


Pelvic Cavity Anatomy
Although the pelvic cavity is in direct continuity with the abdominal cavity, the two regions are delineated by the pelvic inlet (pelvic brim). This lies at approximately 45° to the horizontal and comprises the sacral promontory posteriorly, the arcuate and pectineal lines laterally and the pubic crests and upper border of pubic symphysis anteriorly (Figs 5.1 & 5.26).

Wednesday, November 20, 2019

Calcium Parathyroid Hormone

Calcium Parathyroid Hormone


Calcium Parathyroid Hormone
Clinical scenario
A 55-year-old woman, Mrs CB, had a routine blood test at her general practitioners and was found to have a serum calcium level of 2.88 mmol/L. She was referred to the local endocrine clinic. She was completely asymptomatic, having none of the classical symptoms associated with hypercalcaemia such as bone pain, abdominal pains, renal colic, thirst, polyuria or tiredness. Further investigations confirmed a high serum calcium in association with a low serum phosphate, normal Vitamin D concentrations, a raised 24-hour urine calcium excretion and an elevated serum parathyroid hormone concentration. Sestamibi radioisotope scanning revealed a single abnormality in the upper right parathyroid gland and subsequent surgery confirmed the presence of a single parathyroid adenoma.
Obesity Insulin Resistance and Endocrine Complications

Obesity Insulin Resistance and Endocrine Complications


Obesity Insulin Resistance and Endocrine Complications
Clinical background
Metabolic syndrome
Obesity is associated with a number of metabolic consequences characterized by insulin resistance and hyperlipidaemia. These in turn contribute to the increased risk of cardiovascular disease and diabetes (Fig. 48a and Table 48.1). Metabolic syndrome is the term given to a range of metabolic disturbances occurring in the same patient, all of which should be addressed and modified. Patients with metabolic syndrome have insulin resistance, which precedes the onset of hypertension and Type 2 DM and is thought to represent the primary pathological disturbance. Metabolic syndrome thus describes insulin resistance, hyperinsulinaemia, hypertension, hypertriglyceridaemia, low HDL- cholesterol and obesity. Patients with metabolic syndrome are at a high risk of macrovascular disease and treatment should be aimed at improving insulin sensitivity by diet and exercise and aggressive treatment of hyperlipidaemia.
Obesity Cardiovascular and Respiratory Complications

Obesity Cardiovascular and Respiratory Complications


Obesity Cardiovascular and Respiratory Complications
Clinical background
Obesity is associated with a number of complications and comorbidities. Cardiovascular disease is the major cause of death in obese patients and there is a direct link between the degree of obesity and the degree of hypertension. Other risk factors for coronary heart disease, such as smoking and hyper- lipidaemia, should be addressed. There is also a higher risk of thromboembolism and stroke in the obese population. Other complications include osteoarthritis, back pain, ligament and tendon injury, gallstones and an increased risk of certain cancers, in particular those of the colon, rectum, breast, endometrium and prostate (Fig. 47a). Sleep apnoea syndrome is more common in the obese, particularly men.
Obesity Causes of Obesity

Obesity Causes of Obesity


Obesity Causes of Obesity
Clinical background
Obesity is a global problem in public health and rates of obesity are increasing throughout the world (Fig. 46a). The World Health Organization has defined obesity as ‘abnormal or excessive fat accumulation in adipose tissue to the extent that health is impaired’. Obesity is associated with an increased risk of Type 2 diabetes, hypertension, hyperlipidaemia, cardiovascular disease, sleep apnoea syndrome and respiratory failure, subfertility, arthritis and gallbladder disease. Targets are set using the measurement of Body Mass Index (BMI; weight [kg] / height2 [m2]) (Table 46.1).
Energy Homoeostasis Summary

Energy Homoeostasis Summary


Energy Homoeostasis Summary
Clinical background
In recent years, adipose tissue has become recognized as a highly metabolically active organ. In 1994, the hormone leptin was identified, a peptide almost exclusively secreted by adipose cells and with receptors both in the hypothalamus and peripheral tissues. Leptin has a number of actions both in relation to signalling satiety and altering energy metabolism. The identification of a rare family with leptin deficiency, extreme obesity and insulin resistance was followed by treatment of two children with recombinant leptin and successful loss of weight. However, in the majority of non-leptin-deficient obese individuals, circulating leptin levels are high and correlated with body fat mass, suggesting that leptin resistance may play a role in human obesity. Further work is needed to establish the exact role of this hormone in energy homeostasis.

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