Cushing’s syndrome occurs as a result of increased endogenous or exogenous steroids. The diagnosis is considered when the classic clinical features are recognised. There are several causes of Cushing’s syndrome, but Cushing’s disease specifically refers to an ACTH-secreting pituitary tumour, leading to bilateral adrenal hyperplasia and excess cortisol secretion. Systematic biochemical evaluation is essential to accurately confirm the presence of Cushing’s syndrome and determine the source of excess steroid. Cushing’s syndrome can be a challenging condition both in terms of diagnosis and treatment.