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Introduction to The Cardiovascular System

Introduction to The Cardiovascular System
The cardiovascular system comprises the heart and blood vessels, and contains 5.5 L of blood in a 70 g man. Its main functions are to distribute O2 and nutrients to tissues, transfer metabolites and COto excretory organs and the lungs, and transport hormones and components of the immune system. It is also important for thermoregulation. The cardiovascular system is arranged mostly in parallel, i.e. each tissue derives blood directly from the aorta (Fig. 16a). This allows all tissues to receive fully oxygenated blood, and flow can be controlled independently in each tissue against a constant pressure head by altering the resistance of small arteries (i.e. arteriolar constriction or dilatation). The right heart, lungs and left heart are arranged in series. Portal systems are also arranged in series, where blood is used to transport materials directly from one tissue to another, such as the hepatic portal system between digestive organs and the liver. The function of the cardiovascular system is modulated by the autonomic nervous system (Chapter 7).

Introduction To The Cardiovascular System

Blood vessels
The vascular system consists of arteries and arterioles that take blood from the heart to the tissues, thin-walled capillaries that allow the diffusion of gases and metabolites, and venules and veins that return blood to the heart. The blood pressure, vessel diameter and wall thickness vary throughout the circulation (Fig. 16b,c). Varying amounts of smooth muscle are contained within the vessel walls, allowing them to constrict and alter their resistance to flow (Chapters 11 and 21). Capillaries contain no smooth muscle. The inner surface of all blood vessels is lined with a thin monolayer of endothelial cells, important for vascular function (Chapter 21). Large arteries are elastic and partially damp out oscillations in pressure produced by the pumping of the heart; stiff arteries (age, atherosclerosis) result in larger oscillations. Small arteries contain relatively more muscle and are responsible for controlling tissue blood flow. Veins have a larger diameter than equivalent arteries, and provide less resistance. They have thin, distensible walls and contain 70% of the total blood volume (Fig. 16c).
Large veins are known as capacitance vessels and act as a blood volume reservoir; when required, they can constrict and increase the effective blood volume (Chapter 21). Large veins in the limbs contain one-way valves, so that when muscle activity (e.g. walking) intermittently compresses these veins they act as a pump, and assist the return of blood to the heart (the muscle pump).

The heart
The heart is a four-chambered muscular pump which propels blood around the circulation. It has an intrinsic pacemaker and requires no nervous input to beat normally, although it is modulated by the autonomic nervous system (Chapter 7). The volume of blood pumped per minute (cardiac output) is 5 L at rest in humans, although this can increase to above 20 L during exercise. The volume ejected per beat (stroke volume) is 70 mL at rest. The ventricles perform the work of pumping; atria assist ventricular filling. Unidirectional flow through the heart is maintained by valves between the chambers and outflow tracts. Contraction of the heart is called systole (pronounced sis-to- ley) ; the period between each systole, when the heart refills with blood, is called diastole (di-as-to-ley).

The systemic circulation
During  systole,  the  pressure  in  the  left  ventricle  increases  to 120 mmHg, and blood is ejected into the aorta. The rise in pressure stretches the elastic walls of the aorta and large arteries, and drives blood flow. Systolic pressure is the maximum arterial pressure during systole (110 mmHg). During diastole, arterial blood flow is partly maintained by elastic recoil of the walls of large arteries. The minimum pressure reached before the next systole is the diastolic pressure (80 mmHg). The difference between the systolic and diastolic pressures is the pulse pressure. Blood pressure is expressed as the systolic/diastolic arterial pressure, e.g. 110/80 mmHg. The mean blood pressure (mean arterial pressure, MAP) cannot be calculated by averaging these pressures, because for 60% of the time the heart is in diastole. It is instead estimated as the diastolic pressure plus one-third of the pulse pressure, e.g. 80 + 1/3(110 − 80) ≈ 90 mmHg.
The major arteries divide repeatedly into smaller muscular arteries, the smallest of which (diameter <100 μm) are called arterioles. Tissue blood flow is regulated by the constriction of these small arteries, referred to as resistance vessels. The mean blood pressure at the start of the arterioles is 65 mmHg. The arterioles divide into dense networks of capillaries in the tissues, and these rejoin into small and then larger venules, the smallest veins. Capillaries and small venules provide the exchange surface between blood and tissues, contain no smooth muscle and are called exchange vessels; some gas exchange also occurs across the walls of small arterioles. The pressure on the arterial side of capillaries is 25 mmHg and, on the venous side, 15 mmHg. Venules converge into veins and finally the vena cava. This returns the  partially deoxygenated  and CO2- loaded blood to the right atrium. The pressure in the vena cava at the level of the heart is called the central venous pressure (CVP), and is close to 0 mmHg.

The pulmonary circulation
The right atrium helps to fill the right ventricle, which pumps blood into the pulmonary artery and lungs. The pulmonary circulation is shorter than the systemic, and has a lower resistance to flow. Less pressure is therefore required to drive blood through the lungs; the pulmonary artery pressure is 20/15 mmHg. Gas exchange occurs in capillaries surrounding the alveoli (small air sacs) of the lungs. These rejoin to form pulmonary venules and veins, and oxygenated blood is returned through the pulmonary vein to the left atrium, and hence to the left ventricle. The metabolic requirements of the lungs are not met by the pulmonary circulation, but by the separate bronchial circulation, the venous outflow of which returns to the left side of the heart (Fig. 16a).