NORMAL ELECTRICAL FIRING PATTERNS OF CORTICAL NEURONS AND THE ORIGIN AND SPREAD OF SEIZURES
The collective electrical activity of the cerebral cortex can be monitored by electroencephalography (EEG).
Normal cortical electrical activity reflects the summation of excitatory and inhibitory actions, which is modulated through feedback circuits. Thalamic inputs to the cortex can drive electrical excitability; the midbrain can provide inhibitory control over this process. Repetitive cortical activation can dampen inhibition, enhance excitatory feedback circuits, and recruit repetitive excitatory circuitry in adjacent cortical neurons. These self-perpetuating excitatory feedback circuits can initiate and spread seizure activity.