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Saturday, March 6, 2021



Cervical insufficiency is characterized by asymptomatic dilation of the internal os during pregnancy. This generally leads to dilation of the entire cervical canal during the second trimester with subsequent risk of rupture of the membranes and/or expulsion of the fetus. This affects 1/54 to 1/1842 pregnancies (resulting from uncertain diagnostic criteria). Though uncommon, it is thought to be involved with as many as 20% to 25% of all second-trimester pregnancy losses.

Cervical insufficiency may come from iatrogenic sources, most often damage from cervical dilation at the time of dilation and curettage or other manipulation, or damage caused by surgery (conization). Other possible causes include congenital tissue defect, uterine anomalies (uterus didelphys), prior obstetric lacerations, and in utero exposure to diethylstilbestrol.

Plate 12-12

Generally cervical insufficiency is suggested by a history of second-trimester pregnancy loss accompanied by spontaneous rupture of the membranes without labor, or rapid, painless preterm labor. The finding of prolapse and ballooning of the fetal membranes into the vagina without labor would strongly suggest cervical insufficiency. Cervical insufficiency must be differentiated from the presence of uterine anomalies, chorioamnionitis, and other sources of midpregnancy loss.

When the patient is at high risk for cervical insufficiency (generally by history) or cervical change is suspected, ultrasonography should be used to assess cervical length. Ultrasonography must also be performed before cervical cerclage to assess for abnormal fetal development. Although cervical length can be measured by ultrasonography, routine use of this has not proven to be an effective screening tool except in the face of a high-risk history. (Normal cervical length is approximately 4.1 cm [±1.02 cm] between 14 and 28 weeks and gradually decreases in length to 40 weeks, when it averages between 2.5 and 3.2 cm.) Signs of cervical funneling and cervical shortening are associated with an increased risk of preterm delivery, but management in the absence of other risk factors is unclear.

Currently the best screening technique remains frequent vaginal examinations beginning around the time of previous cervical change or the second trimester, whichever is earlier. Attempts to define or identify cervical insufficiency by hysterosonography, pull-through techniques with inflated catheter balloons, measurement of cervical resistance to cervical dilators, magnetic resonance imaging, and others have not gained clinical acceptance.

Treatment of cervical insufficiency is by cervical cerclage (placement of a concentric nonabsorbable suture close to the level of the internal cervical os) generally performed between 10 and 14 weeks of gestation. When the suture is placed vaginally, it is generally removed at 38 weeks of gestation. If labor occurs before this point and cannot be stopped, the suture should be removed immediately because of the risk of uterine rupture with an obstructed outlet. Cervical cerclage is occasionally performed transabdominally. When placed in this manner, these sutures are intended to remain permanently and they preclude vaginal delivery. The use of lever pessaries (such as the Smith-Hodge) has been reported to be associated with outcomes similar to those obtained by cerclage, but this modality is infrequently used. Bleeding, uterine contractions, obvious infection, or rupture of the membranes are contraindications to cerclage. Because of scarring after cerclage, some patients require cesarean delivery. With correct diagnosis and cervical cerclage, fetal survival increases from 20% to 80%.

Restriction of activity is often suggested, but evidence that this alters the outcome of pregnancy is lacking. After 24 weeks of pregnancy, bed rest may be the only therapy available because the risk of cerclage to trigger labor may outweigh the potential benefit. Prophylactic antibiotics and β-mimetics (tocolytics) have not been shown to be effective in prophylactic cerclage.

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