Transcription Factors - pediagenosis
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Wednesday, September 19, 2018

Transcription Factors

Transcription Factors
Transcription factors regulate gene expression by controlling the transcription of specific genes or gene families (Fig. 1.8). Typically, they contain at least two domains: a DNA‐binding domain, such as a leucine zipper or helix–loop–helix motif which binds to a specific DNA sequence, and an activation domain, which contributes to assembly of the transcription complex at a gene promoter. Mutation, deletion or translocation of transcription factors underlie many cases of haematological neoplasms (see Chapter 11).

Transcription Factors

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