Anxiolytic Agents - pediagenosis
Article Update

Wednesday, June 9, 2021

Anxiolytic Agents

Anxiolytic Agents

Anxiolytic Agents

Two main categories of anxiolytics are benzodiazepines and mis­cellaneous (eg, buspirone, zolpidem, zaleplon). Subclassification of benzodiazepines is based on speed of onset or duration of action, metabolism, and adverse effects. Benzodiazepines cross the blood­brain barrier and bind to specific receptors on the GABAA complex; these receptors occur in many brain regions. The drugs do not bind to the same sites as does GABA but potentiate GABA action. Benzodiazepines are safer than barbitu­rates (largely obsolete); adverse effects include dependence, ataxia, and drowsiness. Diazepam, chlordiazepoxide, prazepam, and the prodrug clorazepate undergo hepatic metabolism to the intermediate oxazepam. Alprazolam, flurazepam, lorazepam, and triazolam directly undergo conjugation before excretion.

Zolpidem and zaleplon resemble benzodiazepines in pharmacology but differ chemically. Buspirone (an azapirone) acts on 5­HT1A receptors. These last drugs have fewer adverse effects and less abuse potential.

Share with your friends

Give us your opinion

Note: Only a member of this blog may post a comment.

This is just an example, you can fill it later with your own note.