Clinical Depression - pediagenosis
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Thursday, June 10, 2021

Clinical Depression

Clinical Depression

Clinical Depression

Clinical (endogenous) depression, a heterogeneous biopsychologic disorder with genetic predisposition, can occur at any time in life, unrelated to obvious stressors. Treatment is required: approximately 15% of these patients commit suicide. Severe (major depression) and mild (dysthymic disorder) forms exist.

Findings that clinical depression may be related to an imbalance in endogenous amines (5­HT or NE) in the CNS led to the amine hypothesis of etiology and spurred efforts to enhance synaptic action of these amines. Antidepressants are classified according to a presumed mechanism of action or chemical structure. TCAs and heterocyclics nonselectively inhibit both 5­HT and NE. SSRIs enhance drugs metabolized via the cytochrome P­450 pathway. MAOIs inhibit amine metabolism. Adverse effects (eg, mania, agitation, serotonin syndrome) and drug interactions (MAOIs used with TCAs or SSRIs) do occur.

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