UTERINE INVERSION - pediagenosis
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Wednesday, December 1, 2021



Rarely, the uterus can be turned inside out immediately following the delivery of the placenta. Uncommon and most often iatrogenic, this may be associated with catastrophic bleeding and cardiovascular collapse. Incomplete uterine inversion may also occur. (Rarely the condition has also been reported in nonpregnant patients with intrauterine pathology such as a pedunculated leiomyomata or large endometrial polyp.) The prevalence of uterine inversion is estimated to be about 1 in 6500 to 25,000 deliveries.


Inversion of the uterus can occur because of traction on the umbilical cord or downward pressure on the uterine fundus to facilitate delivery of the placenta. This is more likely to occur with excessive force and a poorly contracted uterus or lower uterine segment. Abnormalities of placentation (placenta accreta, increta, or percreta) can increase the risk of this occurring because of the absence of separation of the placenta from the uterine wall in a normal manner. Risk factors for inversion include uterine atony secondary to multiparity (grand multiparity), uterine overdistension (multiple birth, polyhydramnios), a prolonged labor, prolonged oxytocin stimulation, muscle relaxant agents (such as MgSO4), or rapid labor.

The diagnosis of inversion of the uterus must be based on a high degree of suspicion. In some cases, a mass (the uterus) may be seen attached to or directly following the placenta as it delivers. More often, there is simply brisk bright red vaginal bleeding accompanied by bradycardia (due to vagal stimulation) and/or tachy- cardia, hypotension, and vascular collapse due to blood loss. The blood loss associated with uterine inversion can be catastrophic and is often underestimated. Uterine inversion must be differentiated from simple uterine atony following placental delivery, retained placental fragments or undiagnosed genital tract lacerations, which can generally be accomplished by simple clinical examination. Although ultrasonography may be used to verify the diagnosis, this is unnecessary and delays the implementation of therapy.

Uterine inversion is treated by rapid evaluation, fluid support, or resuscitation and calls for anesthesia assistance. A delay in treatment markedly increases the mortality rate. Specific treatment is carried out by the use of uterine relaxing agents to allow the replacement of the uterine fundus (may require general anesthesia with a relaxant agent such as halothane), and may require operative intervention (replacement or hysterectomy). Once the uterine wall has relaxed, gentle manual pressure on the fundus is used to displace it inward and upward until its normal position can be restored and the uterus returned to its normal configuration. Uterotonic agents are then used to obtain uterine contraction and hemostasis. Large-volume fluid replacement should be available and used liberally if there has been significant blood loss. If the placenta is still attached to the uterine wall, it should be left in place until after the uterine fundus has been reduced and returned to its normal location. Antibiotic prophylaxis should strongly be considered following the procedure.

If the uterine fundus cannot be repositioned vaginally through these maneuvers, immediate laparotomy is necessary. This can allow simultaneous maneuvers from above and below. A traction suture can sometimes be placed to assist this effort. If a constriction ring is present and impeding replacement, the use of local anesthetics to break the muscular spasm or incision (generally along the posterior aspect of the uterus) may be needed. The possibility of hysterectomy to control bleeding must always be considered.

Although unrecognized or untreated uterine inversion can end in hysterectomy, hemorrhagic shock, and cardiovascular collapse, if it is rapidly treated, the outcome is generally good.

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